Testicular function in a birth cohort of young men

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Testicular function in a birth cohort of young men.

STUDY QUESTION By investigating a birth cohort with a high ongoing participation rate to derive an unbiased population, what are the parameters and influences upon testicular function for a population not selected with regard to fertility? SUMMARY ANSWER While varicocele, cryptorchidism and obesity may impact on human testicular function, most common drug exposures and the presence of epididy...

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Body mass index and cognitive function: birth cohort effects in young men.

OBJECTIVE Body mass index (BMI) and intelligence quotient (IQ) are associated. We examined whether this association varied by birth cohort. METHODS Among 37,414 Danish conscripts, the association between BMI and IQ overall and by birth cohort was examined. IQ was measured by the Børge Prien's Prøve (BPP) group intelligence test score. RESULTS Compared with men of normal BMI, mean difference...

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Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men

BACKGROUND Filaggrin is an epidermal protein that is crucial for skin barrier function. Up to 10% of Europeans and 5% of Asians carry at least one null allele in the filaggrin gene (FLG). Reduced expression of filaggrin in carriers of the null allele is associated with facilitated transfer of allergens across the epidermis. We hypothesized that these individuals may have increased transdermal u...

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Background: Empagliflozin, selective glucose-sodium inhibitor of the latest drugs in the treatment of type 2 diabetes. Diabetes induced hypogonadism disrupts sexual function. There is a direct relationship between reducing blood glucose and reduced libido. In this project, the anti-diabetic drug Empagliflozin in addition to treatment has been studied, in terms of effect on sexual function. Met...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2015

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/dev244